Five best Amazon PPC agencies for supplement brands (2026)

Business

What happens when a supplement brand with a clinically proven joint health formula can’t break past $50,000 in monthly Amazon sales, even as competitors with generic products dominate the search results?

That was the reality for HakaLife, a premium supplement brand with a loyal customer base and a product that outperformed the competition in every clinical metric. Yet, their Amazon channel was stuck. Ad spend was rising, but conversions lagged. Shoppers scrolled past, lured by cheaper alternatives and flashier listings. 

It wasn’t until they partnered with an Amazon PPC agency for supplement brands—one that understood the nuances of compliance, differentiation, and full-funnel strategy—that their sales engine finally roared to life. Within months, HakaLife added $75,000 in monthly revenue, slashed ACOS by 11%, and built a defensible moat against copycat brands.

If you’re a supplement founder or marketing lead, you know this story isn’t unique. The supplement category on Amazon is a minefield: strict compliance, relentless competition, and a sea of lookalike products. The right Amazon PPC agency for supplement brands isn’t just a vendor—they’re your growth partner, your compliance watchdog, and your creative strategist rolled into one. But how do you separate the agencies that truly move the needle from those that just burn your ad budget?

This guide breaks down exactly what to look for, how the best agencies drive real results, and why a specialized approach is non-negotiable for supplement brands in 2026.

Why supplement brands need a specialized Amazon PPC agency

Let’s get one thing straight: running PPC for supplements on Amazon is not like running ads for yoga mats or phone cases. The stakes are higher, the rules are stricter, and the margin for error is razor-thin.

The unique challenges of the supplement category

• Amazon’s Compliance Maze: Supplement listings are under constant scrutiny. Claims must be substantiated, language must be FDA-compliant, and even a single flagged keyword can get your listing suppressed or your ad account suspended.
• Intense Competition: The supplement category is flooded with private label brands, aggressive price-cutters, and big-budget incumbents. Standing out requires more than just a bigger ad budget.
• High Customer Skepticism: Shoppers are wary of unproven claims and low-quality products. Trust signals, reviews, and clear differentiation are essential.
• Ever-Changing Ad Policies: Amazon regularly updates its advertising policies for supplements, especially around health claims, before-and-after imagery, and targeting options.

A generic Amazon PPC agency may get you clicks, but they won’t protect your brand or drive sustainable growth. You need an agency that lives and breathes supplements—and has the case studies to prove it.

What sets the best Amazon PPC agencies for supplement brands apart?

Not all agencies are created equal. The best Amazon PPC agency for supplement brands brings a blend of compliance expertise, creative strategy, and relentless optimization. Here’s what to look for:

1. Deep Compliance Knowledge

• FDA & FTC Claim Management: They know which claims are allowed, which are risky, and how to craft compliant copy that still converts.
• Listing Audits: Regular reviews to ensure your listings and ads stay within Amazon’s ever-evolving guidelines.
• Crisis Management: If a listing gets flagged or suppressed, they have a playbook for rapid resolution.

2. Category-Specific Creative Strategy

• Differentiation: They help you articulate what makes your supplement unique—whether it’s clinical studies, sourcing, or formulation.
• Trust-Building Visuals: High-quality images, infographics, and video that highlight certifications, ingredients, and real results.
• Review Generation: Systems to ethically and compliantly build a base of authentic reviews, which are critical in this category.

3. Full-Funnel PPC Execution

• Keyword Research for Supplements: They go beyond generic terms, targeting high-intent, low-competition keywords that convert.
• Competitor Conquesting: Smart strategies to win market share from established brands without starting a price war.
• Retargeting & Loyalty: Campaigns that bring back past buyers and nurture repeat purchases—a must for supplements.

4. Data-Driven, Transparent Reporting

• TACoS & ACOS Tracking: Clear, weekly reporting on true profitability—not just vanity metrics.
• ASIN-Level Insights: Granular data to spot winners, cut losers, and double down on what works.
• Proactive Optimization: Daily or weekly campaign tweaks based on real performance, not set-and-forget automation.

5. Proven Track Record in Supplements

• Case Studies: Look for documented wins in the supplement space, not just generic eCommerce brands.
• References: Ask for client testimonials and be wary of agencies that can’t provide them.

Top five Amazon PPC agencies for supplement brands (2026)

1) Olifant Digital — Best All-Around Amazon PPC & Growth Partner

Why they’re #1: Olifant Digital is a full-service eCommerce and Amazon marketing agency that acts like an in-house growth team rather than a typical vendor. They specialize in structured PPC campaign management, deep keyword strategy, listing optimization, and full-funnel growth—for Amazon and beyond.

What makes them stand out:

• Custom growth plans & guaranteed performance: They build tailored strategies based on your product and category goals, with clear KPIs.
• Data-driven PPC: Deep keyword analysis plus campaign optimization to improve ACOS, TACoS, and ROI.
• Full brand support: Beyond PPC, they help with listing creative, SEO, and broader ad management.
• High-impact case studies: Brands report significant Amazon revenue growth and improved profitability.

2) Tinuiti — Best for Enterprise Scale & Full-Funnel Amazon Ads

Best for: Larger supplement brands that need a comprehensive approach across Amazon Search, DSP, and measurement tools. Known for advanced targeting and strategic execution.

3) Teikametrics — Best for AI-Driven Optimization

Best for: Brands that want technology-powered campaigns with continuous learning and bid automation, plus expert managed services.

4) Emplicit (formerly Sunken Stone) — Best for Full Lifecycle Amazon Growth

Best for: Brands that want full support from PPC and creative assets to operational Amazon strategy, especially helpful for expanding catalogs.

5) Nuanced Media — Best for Hands-On PPC + DSP Support

Best for: Mid-market supplement brands looking for an Amazon-focused agency that balances strategy and execution with tailored reporting.

Side-by-side comparison table

Supplement brands that scaled with the right agency

Let’s move beyond theory. Here’s how top supplement brands have transformed their Amazon channels by partnering with a specialized PPC agency.

Case Study: HakaLife’s $75,000 Monthly Sales Surge

HakaLife, a premium joint health supplement brand, was stuck in a rut. Despite a superior product, their Amazon sales plateaued. The problem? Shoppers couldn’t see why their product was worth the premium, and ad spend was being wasted on broad, unqualified keywords.

The Solution:

• Repositioned ad copy to highlight clinical results and premium sourcing.
• Synced SEO and PPC messaging for a seamless shopper journey.
• Launched retargeting campaigns to boost repeat purchases.

The Results:

• +$75,216 in monthly Amazon sales
• 11% reduction in ACOS
• Higher conversion rates and stronger customer retention

Case Study: Beauty by Earth’s 27% Revenue Lift in a Crowded Category

Beauty by Earth, an 8-figure clean beauty and supplement brand, was managing Amazon PPC in-house. As the catalog grew, so did the complexity. Without a scalable system, ad spend ballooned and profitability suffered.

The Solution:

• Comprehensive audit and restructuring of all PPC campaigns by ASIN and match type.
• Multi-layered keyword targeting, including competitor ASINs and category-based campaigns.
• Weekly TACoS reporting for full transparency and rapid optimization.

The Results:

• 27% increase in monthly Amazon revenue
• 5 new product launches scaled to $100K+/month
• Lower wasted spend and higher ROAS

The anatomy of a winning Amazon PPC strategy for supplement brands

A great agency doesn’t just run ads—they build a system for sustainable, defensible growth. Here’s what that looks like in practice.

1. Audit and Foundation

Every engagement should start with a deep dive into your current Amazon presence:

• Listing Compliance Review: Are your claims, images, and keywords within Amazon’s supplement guidelines?
• PPC Account Audit: Where is ad spend being wasted? Which campaigns are driving true incremental sales?
• Competitive Analysis: Who are your real competitors, and how are they positioning themselves?

2. Differentiation and Creative Overhaul

• Unique Value Proposition: What makes your supplement worth paying more for? Clinical studies, ingredient sourcing, certifications?
• Visual Storytelling: Main images, infographics, and video that build trust and answer shopper objections.
• A+ Content: Enhanced brand content that educates and converts.

3. Keyword and Campaign Structure

• Exact Match for High-Intent Buyers: Target supplement-specific terms with clear purchase intent.
• Broad & Phrase for Discovery: Test new keywords and find untapped demand.
• Competitor & Category Targeting: Show up on rival listings and in relevant supplement categories.
• Retargeting: Bring back browsers and past buyers with Sponsored Display and Brand Tailored Promotions.

4. Ongoing Optimization

• Daily Bid Adjustments: React to shifts in competition and seasonality.
• Negative Keyword Management: Cut wasted spend on irrelevant or non-converting terms.
• ASIN-Level Reporting: Double down on winners, cut or fix underperformers.
• Review Monitoring: Proactively manage reviews and address negative feedback.

5. Compliance and Risk Management

• Automated Alerts: Get notified if a listing is flagged or suppressed.
• Rapid Response Playbooks: Have a plan for reinstating listings and resolving compliance issues.
• Ongoing Training: Stay ahead of Amazon’s evolving supplement policies.

How to evaluate an Amazon PPC agency for supplement brands

Choosing the right partner is a high-stakes decision. Here’s a step-by-step process to separate the true experts from the pretenders.

Step 1: Review Their Supplement Track Record

• Ask for Supplement-Specific Case Studies: Not just generic eCommerce wins. Look for brands in your category and similar price points.
• Check for Compliance Wins: Have they helped brands recover from listing suppressions or ad account suspensions?
• Look for Long-Term Partnerships: One-off wins are nice, but sustained growth over 12+ months is the real test.

Step 2: Assess Their Strategic Depth

• Do They Start with an Audit? Beware agencies that pitch a one-size-fits-all package without understanding your brand.
• Can They Articulate Your Differentiation? If they can’t explain what makes your supplement unique, they can’t sell it.
• Are They Proactive or Reactive? The best agencies bring new ideas and spot issues before you do.

Step 3: Evaluate Their Reporting & Communication

• Transparent, Actionable Reporting: You should get weekly or bi-weekly reports with clear insights—not just data dumps.
• Direct Access to Experts: Will you have a dedicated account manager who knows supplements, or just a generic support line?
• Clear Roadmaps: You should know what’s happening next, not just what happened last month.

Step 4: Test Their Compliance Knowledge

• Quiz Them on Supplement Policies: Ask how they handle claims, imagery, and compliance reviews.
• Scenario Planning: What’s their process if a listing is suppressed or a claim is flagged?
• Ongoing Education: Do they stay up-to-date with Amazon’s evolving supplement guidelines?

Step 5: Understand Their Fee Structure

• Performance-Based or Flat Fee? Make sure incentives are aligned with your growth.
• No Hidden Fees: Beware of agencies that nickel-and-dime for every change or report.
• Clear Scope of Work: Know exactly what’s included—PPC only, or full-service Amazon management?

Red flags: Signs an agency isn’t right for your supplement brand

Not every agency that claims to be an Amazon PPC expert is equipped for the supplement category. Watch out for these warning signs:

• No Supplement Case Studies: If they can’t show wins in your category, keep looking.
• Vague on Compliance: If they gloss over compliance or say “we’ll figure it out,” run.
• Set-and-Forget Approach: If they promise results without ongoing optimization, you’ll be left behind.
• Lack of Transparency: If you can’t get clear answers on performance or fees, it’s a bad sign.
• Overpromising: If it sounds too good to be true (“We’ll double your sales in 30 days!”), it probably is.

The Role of Creative in Supplement PPC Success

In supplements, creative isn’t just about pretty pictures—it’s about building trust, answering objections, and making your product the obvious choice.

Main Images That Convert

• Show the Product Clearly: No clutter, no distractions. The supplement bottle should be front and center.
• Highlight Key Benefits: Use callouts for certifications (Non-GMO, Vegan, etc.), ingredient sourcing, or clinical results.
• Lifestyle Context: Show the supplement in use, but avoid before-and-after imagery that violates Amazon’s policies.

Infographics and A+ Content

• Ingredient Transparency: Break down what’s inside and why it matters.
• Usage Instructions: Make it easy for shoppers to understand how and when to take your supplement.
• Trust Signals: Display third-party certifications, lab results, and customer testimonials.

Video Ads

• Educate Quickly: Explain the problem, your solution, and why it works—in 30 seconds or less.
• Show Real People: Authentic testimonials build credibility.
• Stay Compliant: Avoid unsubstantiated claims or risky language.

Advanced PPC tactics for supplement brands in 2026

The Amazon ad landscape is evolving fast. Here’s how the best agencies are staying ahead:

1. AI-Powered Keyword Expansion

• Dynamic Keyword Mining: Use AI tools to uncover emerging search terms and trends in the supplement space.
• Real-Time Bid Adjustments: Algorithms that react instantly to shifts in competition or seasonality.

2. Audience Targeting and Retargeting

• Sponsored Display Audiences: Target shoppers who viewed your product, similar products, or relevant categories.
• Brand Tailored Promotions: Custom offers for repeat buyers or high-intent browsers.
• Lookalike Audiences: Reach new customers who resemble your best buyers.

3. Cross-Channel Attribution

• Track Off-Amazon Impact: Measure how Google, Facebook, or influencer campaigns drive Amazon sales.
• Unified Reporting: See the full picture, not just siloed channel data.

4. Defensive and Offensive Strategies

• Defend Your Brand: Bid on your own brand terms to block competitors.
• Conquest Competitors: Target rival ASINs with Sponsored Product and Sponsored Brand ads.
• Seasonal Campaigns: Ramp up spend around New Year’s, summer, or other peak supplement buying seasons.

How to onboard with an Amazon PPC agency for supplement brands

Once you’ve chosen your agency, a smooth onboarding process sets the stage for success. Here’s what to expect.

1. Kickoff and Discovery

• Brand Deep Dive: Share your brand story, product USPs, and compliance documentation.
• Access & Permissions: Grant access to your Amazon Seller Central, Brand Registry, and ad accounts.
• Goal Setting: Define clear KPIs—revenue targets, ACOS/TACoS goals, new product launches, etc.

2. Audit and Strategy Development

• Comprehensive Account Audit: Identify quick wins and long-term opportunities.
• Competitive Benchmarking: See how you stack up against top supplement brands.
• Custom Roadmap: Get a step-by-step plan tailored to your brand and category.

3. Creative and Listing Optimization

• Image & Copy Overhaul: Refresh visuals and copy for compliance and conversion.
• A+ Content & Storefront: Build out enhanced content to tell your brand story.
• Review & Q&A Management: Set up systems to monitor and respond to customer feedback.

4. Campaign Launch and Optimization

• Initial Campaign Setup: Launch new PPC campaigns with tight targeting and clear structure.
• Daily/Weekly Optimization: Adjust bids, add negatives, and test new keywords.
• Transparent Reporting: Get regular updates and clear action items.

What does success look like? Key metrics for supplement brands

The best agencies focus on metrics that matter—not just clicks or impressions, but true business outcomes.

1. Revenue Growth

• Monthly Sales Increases: Track incremental revenue driven by PPC and organic improvements.
• New Product Launches: Measure how quickly new supplements gain traction.

2. Profitability

• ACOS (Advertising Cost of Sale): Keep ad spend efficient, especially in a high-competition category.
• TACoS (Total Advertising Cost of Sale): Monitor the impact of ads on total sales, not just ad-attributed sales.

3. Conversion Rate

• Listing Conversion: Are more shoppers buying after clicking your ad?
• Repeat Purchase Rate: Are you building a loyal customer base?

4. Organic Rank & Visibility

• Keyword Rankings: Are you climbing for your most important supplement terms?
• Share of Voice: How often do you appear in top ad placements and organic results?

5. Compliance & Account Health

• Listing Suppressions: Fewer flags and faster resolutions.
• Review Health: More positive reviews, fewer negatives.

Frequently asked questions: Amazon PPC agencies for supplement brands

Q: Can’t I just use a generic Amazon agency?

You can, but you’ll be at a disadvantage. The supplement category is uniquely challenging—compliance, competition, and customer skepticism require a specialized approach. A generic agency may get you clicks, but they won’t protect your brand or drive sustainable growth.

Q: How much should I budget for Amazon PPC in supplements?

It depends on your goals, category competitiveness, and product price point. Most supplement brands allocate 10-20% of revenue to Amazon ads, but the best agencies will help you optimize spend for maximum ROI—not just spend more.

Q: How long does it take to see results?

You’ll often see early wins (lower ACOS, higher conversion) within 30-60 days, but true, sustainable growth takes 3-6 months. The best agencies focus on building a system, not just chasing short-term spikes.

Q: What if my listing gets suppressed?

A specialized agency will have a playbook for rapid resolution—reviewing flagged claims, updating copy, and working with Amazon support. Prevention is key, but fast recovery is essential.

Q: Do agencies help with review generation?

Yes, but only through compliant, ethical methods. Beware of any agency promising to “buy” reviews or use black-hat tactics—it’s not worth the risk.

The right Amazon PPC agency for supplement brands is a growth multiplier

The supplement category on Amazon is unforgiving. Compliance missteps, generic creative, or wasted ad spend can stall even the best products. But with the right Amazon PPC agency for supplement brands, you gain more than just a vendor—you gain a partner who understands the stakes, the rules, and the levers that drive real growth.

Look for an agency with proven supplement wins, deep compliance expertise, and a relentless focus on differentiation and optimization. Demand transparency, strategic depth, and a creative approach tailored to your brand. When you find that partner, you’ll see what’s possible: higher sales, stronger margins, and a brand that stands out in the most crowded category on Amazon.

Ready to see what a specialized agency can do for your supplement brand? Start with a deep-dive audit, ask the tough questions, and don’t settle for less than a true growth partner.