Can you use Kratom for depression and anxiety?

Anxiety and depression are becoming common ailments today due to busy lifestyles, odd working hours, and hectic work schedules. 

However, Kratom has gained attention as a potential aid for depression and anxiety. Active compounds in kratom, such as mitragynine, interact with opioid receptors in the brain, which may help alleviate mood disorders. This has prompted people to consider Kratom for emotional well-being. 

However, caution is advised due to its complex effects and lack of FDA approval. Research indicates that the Anxiety and Depression Association of America (ADAA), nearly 40 million American adults suffer from conditions of anxiety and depression.  This is roughly 18% of the adult population.

Despite these promising figures, Kratom’s safety and efficacy remain under scrutiny. This article examines whether Kratom can be an effective and safe option for managing symptoms of depression and anxiety, considering both its potential benefits and risks.

How should I take Kratom for depression and anxiety?

Taking Kratom for depression and anxiety involves several considerations, including the method of ingestion, timing, and dosage. However, it’s crucial to note that Kratom is not officially recognized as a treatment for these conditions, and its use should be approached cautiously. Here are general guidelines on how to take Kratom.

Choose the right strain

Different strains of Kratom have different effects. For depression and anxiety, Red Vein and some Green Vein strains are often preferred for their calming effects.

Method of ingestion

  • Powder: Kratom powder can be mixed with water or juice or brewed as tea. It’s fast-acting but can have a strong taste.
  • Capsules: It is also available in the form of premium kratom pills that are convenient to take with the appropriate amount of powder in it. It also masks the taste, but they may take longer to have an effect.
  • Tinctures and Extracts: These are potent and fast-acting but can increase the risk of tolerance and side effects.


Start with a low dose (1-2 grams) to assess tolerance and effects. A moderate dose (3-5 grams) may be more effective for mood enhancement and anxiety relief, but individual responses can vary.


Take Kratom during the time of day when you feel your symptoms are most challenging. Some prefer to take it in the morning to combat morning anxiety or lethargy, while others might find it more beneficial in the evening to promote relaxation.

Monitor your reaction

Pay attention to how your body and mind respond. Adjust the timing and dosage as needed, but avoid increasing the dose frequently to prevent tolerance and dependency.

Lifestyle considerations

Combine Kratom use with healthy lifestyle choices like regular exercise, a balanced diet, and good sleep hygiene for the best results in managing depression and anxiety.

How does Kratom affect your mood?

Kratom, known scientifically as Mitragyna speciosa, affects mood through its active compounds, primarily mitragynine and 7-hydroxymitragynine. These compounds interact with the brain’s opioid receptors, though they don’t bind to these receptors in the same way as traditional opioids. This interaction is key to understanding Kratom’s mood-altering effects:

  • Stimulating Effects at Lower Doses: At lower doses, Kratom acts as a stimulant. Users often report increased energy, alertness, and sociability. This stimulating effect can indirectly influence mood by reducing fatigue and enhancing overall well-being.
  • Sedative Effects at Higher Doses: At higher doses, Kratom provides soothing effects. Happy Go Leafy kratom products can lead to feelings of calmness, and might reduce anxiety, which can be beneficial for individuals experiencing stress or anxiety.
  • Influence on Neurotransmitters: Kratom may also affect the levels of certain neurotransmitters in the brain, such as serotonin and dopamine, both of which play significant roles in mood regulation. By potentially boosting these neurotransmitters, Kratom can create a sense of pleasure and positivity.
  • Variability of Effects: The effects of Kratom on mood are highly variable and depend on numerous factors, including the strain of Kratom, the dosage, the individual’s physiology, and their tolerance level.
  • Temporary Relief from Mood Disorders: Some users have reported temporary relief from symptoms of mood disorders like depression and anxiety. However, these effects are not well-studied and should be approached with caution.
  • Dependency and Withdrawal: Regular use of Kratom, especially in large amounts, can lead to dependency and withdrawal symptoms, which can negatively impact mood and overall mental health.

Which Kratom strains work for  depression and anxiety?

Kratom, with its diverse strains, is thought by some to help with symptoms of depression and anxiety, though scientific research in this area is still limited. Each strain has different effects, which can vary from person to person. Here are some commonly mentioned strains for these conditions:

  • Red Vein Kratom: Known for its calming properties, Red Vein strains like Red Bali Kratom, Red Borneo, and Red Thai are often cited for their potential to alleviate anxiety and stress. They tend to have a higher concentration of 7-hydroxymitragynine, which is believed to produce more sedative effects.
  • Green Vein Kratom: Strains like Green Malay and Green Maeng Da are popular for those seeking a balance between relaxation and energy. These strains are often used for mild anxiety and as mood enhancers, potentially providing a sense of well-being and focus without overstimulation.
  • White Vein Kratom: White strains, such as White Borneo and White Thai, are typically more energizing. They might be beneficial for those with depression who suffer from fatigue and lethargy. However, they might not be the best choice for anxiety, particularly for individuals prone to panic attacks or anxiety-induced insomnia.

How much should you take Kratom for depression and anxiety?

Determining the appropriate dosage of Kratom for depression and anxiety is complex, as it varies widely depending on individual factors such as body weight, tolerance, and the specific strain used.

It’s important to note that how long kratom stays in your system is not officially prescribed or recognized as a treatment for these conditions, and more scientific research is needed to understand its effects fully. However, users often follow general guidelines to minimize the risk of side effects:

  • Start with a Low Dose: If you’re new to Kratom, start with a small dose, typically around 1-2 grams. This can help you gauge your body’s reaction and minimize potential side effects.
  • Moderate Dose for Mood Enhancement: A mild dose of about 3-5 grams is often reported to be effective for mood enhancement and anxiety relief. This can provide a balance between stimulating and sedative effects.
  • Monitor Your Response: Track how your body and mind respond to different doses. Some people may require slightly more, while others need less.
  • Avoid High Doses: High doses (above 8 grams) are more likely to produce sedative solid effects and increase the risk of adverse reactions and dependency.
  • Frequency of Use: Be cautious about how often you use Kratom. Regular use can lead to tolerance, meaning you’ll need higher doses for the same effect, and it can also lead to dependence.

Can you use Kratom for depression and anxiety?

Kratom, with its diverse strains and active alkaloids, has emerged as a substance of interest for potentially alleviating symptoms of depression and anxiety. The way Kratom interacts with the brain’s opioid receptors suggests it can have mood-enhancing effects, ranging from stimulating at lower doses to sedative at higher doses.

Strains like Red Vein and Green Vein are often favored for their calming properties, while White Vein strains are noted for their energizing effects. However, determining the correct dosage is complex and varies per individual, emphasizing the need for cautious use and monitoring of personal responses.

Users must approach Kratom use with an understanding of the risks, including dependency and potential side effects. It’s also vital to consider lifestyle factors and consult healthcare professionals, especially when managing mental health conditions.

As with any substance used for health-related purposes, thorough personal research and professional advice are crucial in making informed decisions about using Kratom for depression and anxiety.